Tagged with “COIN”
ArchivesNew Data on COIN
At the ECCO/ESMO meeting in Berlin the data on a large phase III clinical trial from the United Kingdom (COIN) was presented. It was a trial comparing FOLFOX or XELOX in combination with Erbitux.
It is important to know that in the UK Avastin is not approved, and Erbitux was only recently approved in patients with organ limited disease based on the chance of curative resections in patients initially deemed not to be resectable. However it is difficult to judge what the COIN results mean. The response rates in the patients with wild-type KRAS was significantly increased to 64%, so far so good. The problem is that the time to tumor progression and overall survival was not improved in patients with wild-type KRAS and Erbitux therapies. Continue reading…
Posted by Heinz-Josef Lenz, MD on October 19th, 2009
Posted in: From the Desk of Dr. Lenz | 2 Comments »
Tags: cetuximab, clinical trials, COIN, Erbitux
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