Tagged with “recurrence risk”

Stage II Recurrence Test Now Available

How likely is it that an individual colon cancer will return?

Stage II colon cancer patients have a tough time knowing how likely it is that their cancer will recur and making a decision about having chemotherapy after surgery.

A test is now on the market that can help with that decision. OncoType DX® Colon Assay analyzes 12 key genes from a tumor sample to produce a recurrence score that indicates how likely stage II colon cancer will return.

While OncoType DX Colon can’t predict whether chemotherapy will reduce the chance that cancer will come back, it can help patients and their doctors decide on chemotherapy in combination with other factors.

Posted by Kate Murphy on February 25th, 2010
Posted in: Research & Treatment News | No Comments »
Tags: Oncotype DX, recurrence risk, stage II colon cancer

To Chemo or Not to Chemo: Evaluation of the Risk of Recurrence in Stage II Patients

Here’s a second article from C3 research advocate, Pam McAllister, based on information she learned at the 2010 GI Cancers Symposium in Orlando.

Pam’s experience with colorectal cancer research advocacy goes back more than a decade. She has been a patient advocate with several cancer cooperative groups and now chairs the Radiation Therapy Oncology Group (RTOG) Patient Advocacy Committee.

While most patients with stage II colon cancer are at low risk of recurrence, there are patients in this group who are at increased risk and who may need chemotherapy to reduce their risk. Continue reading…

Posted by Pam McAllister on February 15th, 2010
Posted in: Research & Treatment News | No Comments »
Tags: 2010 GI Cancers Symposium, recurrence risk, stage II colon cancer

Older patients benefit from XELOX after surgery

Update from 2010 GI Cancers Symposium

Colon cancer patients over 70 actually had a greater reduction in disease-free survival than did younger ones with a new regimen of Xeloda® and oxaliplatin compared to older IV 5-FU treatments according to a new analysis reported at the GI Cancers Symposium in Orlando.

With the bolus IV 5-FU and leucovorin regimens, stage III colon cancer patients over 70 had about a 60 percent chance of being alive and free from cancer three years after surgery. With a combination of Xeloda (capecitabine) and oxaliplatin in a treatment called XELOX, their three-year disease-free survival was 66 percent.

Younger patients had about a 3 percent absolute improvement between the two treatments from 69 percent to 72 percent. Continue reading…

Posted by Kate Murphy on January 25th, 2010
Posted in: Research & Treatment News | 1 Comment »
Tags: capecitabine, elderly, oxaliplatin, recurrence risk, Xeloda

Dr. Lenz: Genetic Signature Not Helpful to Predict Recurrence in Clinical Practice

At ASCO 2009 Dr. David Kerr from the United Kingdom presented data on a genetic signature which is associated with tumor recurrence in stage II colon cancer. However these data are not even close to being clinically meaningful.

These data have been discussed by Kate Murphy. However I wanted to follow up with the significance of the data. To increase the risk of recurrence from 12% to 22% is not in any way or form helpful in the clinic, particularly because this outcome is independent of treatment effect. Continue reading…

Posted by Heinz-Josef Lenz, MD on June 25th, 2009
Posted in: From the Desk of Dr. Lenz | No Comments »
Tags: ASCO 2009, genetic signature, recurrence risk, Understanding Genetics